Rapamycin 53123-88-9 Pharmaceutical Powder of Organ Transplantation Rejection in Trial
|FOB Price:||US $0.5-1 / Gram|
|Min. Order:||10 Gram|
|Min. Order||FOB Price|
|10 Gram||US $0.5-1/ Gram|
|Payment Terms:||T/T, Western Union, Money Gram, Bitcion|
- Model NO.: 98%
- Customized: Customized
- Suitable for: Adult
- Purity: >98%
- Delivery Ways: EMS, Hkems, TNT, DHL, FedEx, UPS etc.
- Other Service: We Confirm 98% Clearance, 100% Resending.
- Price: Negotiable( The Greater The Amount, The Greate)
- Transport Package: as You Requst
- Origin: China
- Powder: Yes
- Certification: ISO 9001, USP, BP, RoHS
- State: Solid
- Delivery Port: Express Courier
- Shipment Time: Within 8 Hours After Confirmation of Your Payment
- MOQ: 10 Vials
- Trademark: ShuCan
- Specification: 98% min
Product Name: Rapamycin
Synonyms: AY 22989;23,27-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOHENTRIACONTINE;NSC-226080;RAPA;RAPAMUNE;RAPAMYCIN;RAPAMYCIN, STREPTOMYCES HYGROSCOPICUS;RPM
Mol File: 53123-88-9.mol
Fp 87 °C
storage temp. -20°C
Sensitive Moisture Sensitive/Light Sensitive/Hygroscopic
Hazard Codes Xi,Xn,F
Risk Statements 36/38-36-20/21/22-11
Safety Statements 22-24/25-37/39-26-36/37-16
Usage And Synthesis:
Rapamycin (RAPA) is a new type of large ring lactone immunosuppressant. It is white solid crystal, melting point of 183-185 oC, lipophilic, soluble in methanol, ethanol, acetone, chloroform and other organic solvents, very slightly soluble in water, hardly soluble in ether. It was developed in the early 1970s, initially was as low toxicity antifungal drugs, and was found immunosuppressive in 1977. From 1989, RAPA was as a new drug for the treatment of organ transplantation rejection in trial, and from animal experiments and clinical application effects, it is of good curative effects, low toxicity and no new immunosuppressant nephrotoxicity. Now rapamycin is frequently as maintaining immunity drug for transplant organs (especially kidney transplant), to slow down the immune rejection of the organ in transplant surgery, however, scientists recently discovered another purpose: it can be used in the treatment of alzheimer's disease (senile dementia). To their interest, the main composition of rapamycin exists in Easter island isolated bacteria in the soil, and recent experiments show that the material used in the experimental rats can have ability to restore the memorization defects on the body.
Rapamycin is a large ring lactone antibiotic, it has the similar composition with Zyprexa (FK506), but has very different mechanism of immunosuppression. FK506 suppressor T lymphocyte proliferation from G0 to G1 phase, whereas RAPA blocks signal transduction through different cells, and the process of T cells and other cells from G1 phase to S phase. Compared with FK506, RAPA blocks the signal pathways of T lymphocytes and B lymphocytes depended on calcium or not.
Medical researchers from University of Chicago combined commercially available rapamycin oral tablets with grapefruit juice in the treatment of melanoma (a kind of malignant tumor disease common in European and American people), which could greatly improve the anticancer effect of other chemotherapy drugs, thereby prolong the survival time of patients. Studies have shown that rapamycin is easy to decompose by enzyme on entering the digestive tract, and the grapefruit juice contains a large number of coumarin and furan, which can inhibit the digestive enzymes from damaging the effects of rapamycin, so it can improve the bioavailability of rapamycin. It is said that the earliest Dutch doctor had found: grapefruit juice have a function to improve the oral absorption effect of sandimmune, which now is applied to the formulation of rapamycin by the European and American doctors.
(2).Targeted Cancer Therapy Drugs
In recent years, studies found that as an intracellular kinase, the pathway abnormality of rapamycin target protein (mTOR) may induce many diseases. Rapamycin as mTOR's targeted inhibitor, can treat the tumors closely related to the pathway including kidney cancer, lymphoma, lung cancer, liver cancer, breast cancer, neuroendocrine carcinoma and gastric cancer, etc. Especially for LAM (lymphatic fibroid disease) and TSC tuberous sclerosis - the treatment effect of the two kinds of rare diseases is more apparent, and to some extent LAM and TSC can be considered as tumor diseases.
Rapamycin (RAPA) has similar side effects to FK506. Found in a large number of clinical trials, its side effects are dose dependent, and reversible, therapeutic dose RAPA have not been found to have obvious renal toxicity, no gingival hyperplasia. Main side effects include headache, nausea, dizziness, nose bleeding, joint pain. Laboratory abnormalities include: thrombocytopenia, leukopenia, lower hemoglobin, high blood triglycerides, high cholesterol, high blood sugar, elevated liver enzymes (SGOT, SGPT), lactate dehydrogenase, low potassium, low magnesium levels, etc. Recently there have been reports that RAPA can produce eyelid edema, and the cause of the low level of plasma phosphate was thought to be RAPA immunosuppressive therapy on the basis of the extended phosphate from the elimination of the transplanted kidney. Like other immunosuppressants, RAPA increases the chance of infection, there are reports on pneumonia increasing, but the other opportunistic infection has no obvious difference between CsA.
|State:||Liquid or Powder|
|Appearance:||White Crystalline Powder or Oil|
|Payment:||Western Union, Moneygram, T/T,Bitcion|
|Delivery:||We have stock, so we can delivery quickly at the very day when receive the payment. 100%Door to Door|
|Shipment:||Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.|
|Customs clearance||Don't have to worry about cystoms pass rate,our customs clearance is 100%|
|Product packing||The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .|
|After-sales service||Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.|
|Advantage of Our Company|
1,Professional medical products manufacture for more than 15 years
2,High quality with competitive price
3,Independent Design and Outstanding Sales Team
4,Large Supply Ability
5,Excellent after-sales service
1. Any Inquiries will be replied within 24 hours
2.Hight quality, fashion designs reasonable & competitive price. fast lead time.
3.Payment: You can pay for the order via: T/T, Western Union, MoneyGram
4. After Sale Service:
1).All products will have been strictly Quality Checked in house before packing.
2).All products will be well packed before shipping.
3)Parcel can be sent out in 24 hours after payment. Tracking number available
4)Secure and discreet shipment. Various transportation methods for your choice.
5)Customs pass rate ≥99%
6) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and
we have stock in there for transferring.
we have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air PostYou also can choose
your own shipping forwarder.
Sample Policy:You need pay for sample first if you want to check it and the money will be refunded when
mass order confirmed.
Payment Way: T/T,Western Union, Money Gram
Delivery Date: within 10 working days after deposit paid
Shipping Way: By Sea or By Air
After Service: When you receive the goods, please check the product and its quantity in time, Once
Problems arised , pls contact us and we will help you solve the problem.
1. How about the Delivery time?
We will arrange the delivery within 24 hours after receiving the payment,except for custom products.
2. What kind of payments does you support?
T/T, Western Union, PayPal & Cash are accepted.
3. What's the MOQ?
Generally speaking, the MOQ is 10 gram, but we also can provide you samples for quality inspection.
4. Do you charge for the samples?
According to our company policy, we just charge the samples based on EXW price. And we will return
the samples fee during the next order.
5. Can you packing according to customers' requirements ?
Sure,If you have a request for packing, please tell us,Any good ideas are welcomed.
6. Can you tell me your main customers?
That's our customer's privacy, we should protect their information.
At the same time, please rest assured that your information is also safe here.
We'll offer you the quotation as soon as possible once receive your inquiry, so don't hesitate to contact us.
|How to Proceed Your Orders?|
Please let me know the items you are favorable, quantities, and the destination country.
You confirm all details, and offer us purchasing order.
We send the detail price of our product and offer the suitable shipping method for reference.
You confirm the order and pay money 100% in advance and send us the detailed contacting information,
including contacting person/company, address, mobile number,ZIP code and your special requirements.
Parcel would be arranged within 12 hours upon receipt of your payment .
Photos would be offered to tell apart the products .
Tracking number :
Send by EMS, the tracking number is availabe within 12 hours . The info would be trackable that day or 1
If send by HKEMS or other express,the tracking number would be provided next day. And this does not
mean the info is trackable that day. It would be released on internet 2 or 3 days later . The reason why is
that parcel should be shipped to Hongkong from forwarder then wait for the flight .
You sign for the parcel , deliveried.
We offer after-sales service after you receive parcel.
|Any question, email me, I am sherry.|
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