Ketotifen Fumarate 34580-14-8 Pharmaceutical for Asthma and Childhood Asthma
|FOB Price:||US $0.5-1 / Gram|
|Min. Order:||10 Gram|
|Min. Order||FOB Price|
|10 Gram||US $0.5-1/ Gram|
|Transport Package:||as You Requst|
|Payment Terms:||T/T, Western Union, Money Gram, Bitcion|
- Model NO.: 98%
- Customized: Customized
- Suitable for: Adult
- Purity: >98%
- Delivery Ways: EMS, Hkems, TNT, DHL, FedEx, UPS etc.
- Other Service: We Confirm 98% Clearance, 100% Resending.
- Price: Negotiable( The Greater The Amount, The Greate)
- Specification: 98% min
- Powder: Yes
- Certification: ISO 9001, USP, BP, RoHS
- State: Solid
- Delivery Port: Express Courier
- Shipment Time: Within 8 Hours After Confirmation of Your Payment
- MOQ: 10 Vials
- Trademark: ShuCan
- Origin: China
Product Name: Ketotifen fumarate
Synonyms: 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-pipe;hc20-511fumarate;zaditen;4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9h)-one hydrogen fumarate;4,9-DIHYDRO-4-(1-METHYL-4-PIPERIDINYLIDENE-10H-BENZO[4,5]CYCLOHEPTA[1,2-B]THIOPHEN-10-ONE) FUMARATE;KETOTIFEN FUMARATE;KETOTIFEN FUMARATE SALT;4,9-dihydro-4-(1-methylpiperidin-4-ylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophene-10-one fumarate
Mol File: 34580-14-8.mol
MP 192 C
Appearance :This product is white (or light-yellow) crystalline powder, and is odorless with bitter taste. It is slightly soluble in water and ethanol, and easily soluble in methanol but very slightly soluble in chloroform and acetone.
storage temp. Store at RT
CAS DataBase Reference 34580-14-8(CAS DataBase Reference)
Hazard Codes Xn,T
Risk Statements 22-36/37/38-23/24/25
Safety Statements 36-45-36/37/39-26
WGK Germany 3
4.Usage And Synthesis:
Ketotifen fumarate is a kind of strong anti-allergic drugs containing simultaneously of both tricyclic structure as well as piperidine structure. It is characterized by both a strong antagonism effect on histamine H1 receptor and inhibitory effect of the release of the mediator of allergic reaction. It can inhibit the release various kinds of mediators of mast cells, basophils and macrophages, including the release of slow reacting substances and other active substances. It also has antagonism effect on the calcium ion; can inhibit the activity of phosphodiesterase; increase the intracellular cAMP level inside mast cells. Moreover, it can also inhibiting the chemotaxis and inflammation of neutrophil with an effect 10 times as strong as that of chlorpheniramine, and it also has a long duration time which is better compared with sodium cromolyn. Ketotifen fumarate has therapeutic effect on both I and III type of allergic reaction. Its peak blood concentrations can sustain for 2 to 3 hours with a half-life of 22 hours during which 60% goes through urinary excretion, 40% goes through the fecal excretion. Children usually have a faster excretion rate of it than adults. Long-term treatment will not cause resistance. No rebound phenomenon will occur with interruption of treatment.
Dermatology applies it to the treatment of allergic diseases such as urticaria, pruritus, eczema, atopic dermatitis, and neurodermatitis; it is recently reported that it is also effective in the treatment of scleroderma. For medicine, it has a good efficacy in treating asthma, especially with a significant effect on treating allergic asthma, followed by mixed asthma, and being effective in half of cases for infecting type. It can also be used for the prevention of asthma.
It has been more than 20 years since ketotifen fumarate have been applied to the prevention and treatment of asthma and childhood asthma. It is a kind of drug with dual effect of both prevention and treatment in the prevention and treatment of asthma and childhood asthma. It should be particularly noted that ketotifen had ever taken as the long-term controlling drug of asthma and childhood long-term asthma and was subject to wide application in many countries. Since the early 1980s, ketotifen fumarate had already been applied in Western Europe, Asia, and our country for the prevention and treatment of asthma and asthma in children. But since entering into 21st century, the annual applied amount has decreased year by year. Because of its side effect of inhibition of the central nervous system, its oral tablet currently has still not approved by the FDA and thus failing to enter the US market with only ketotifen fumarate eye drops (ZADITOR) had been approved by the FDA in 1999. Recent studies have also shown the effectiveness of ketotifen asthma still demands further studies. Moreover, ketotifen fumarate has several additional advantages. First, it can cause sleepiness of the schoolchildren and thus being able to affect their academic performance; second, it can also do harm to the mental development of infants and young children. Thirdly, it is also be able to affect the metabolism of sustained-release tea and thus negatively affecting its anti-inflammatory effects of theophylline. For all the above points, it is not recommended by the GINA (affiliated organization of WHO) to apply ketotifen fumarate for the treatment and prevention of asthma and childhood asthma. But from the perspective of clinical economics, ketotifen fumarate is a suitable anti-allergic drug for being applied in developing countries and rural areas for treating asthma and childhood asthma with certain efficacy due to its relative low price.
|State:||Liquid or Powder|
|Appearance:||White Crystalline Powder or Oil|
|Payment:||Western Union, Moneygram, T/T,Bitcion|
|Delivery:||We have stock, so we can delivery quickly at the very day when receive the payment. 100%Door to Door|
|Shipment:||Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.|
|Customs clearance||Don't have to worry about cystoms pass rate,our customs clearance is 100%|
|Product packing||The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .|
|After-sales service||Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.|
|Advantage of Our Company|
1,Professional medical products manufacture for more than 15 years
2,High quality with competitive price
3,Independent Design and Outstanding Sales Team
4,Large Supply Ability
5,Excellent after-sales service
1. Any Inquiries will be replied within 24 hours
2.Hight quality, fashion designs reasonable & competitive price. fast lead time.
3.Payment: You can pay for the order via: T/T, Western Union, MoneyGram
4. After Sale Service:
1).All products will have been strictly Quality Checked in house before packing.
2).All products will be well packed before shipping.
3)Parcel can be sent out in 24 hours after payment. Tracking number available
4)Secure and discreet shipment. Various transportation methods for your choice.
5)Customs pass rate ≥99%
6) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and
we have stock in there for transferring.
we have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air PostYou also can choose
your own shipping forwarder.
Sample Policy:You need pay for sample first if you want to check it and the money will be refunded when
mass order confirmed.
Payment Way: T/T,Western Union, Money Gram
Delivery Date: within 10 working days after deposit paid
Shipping Way: By Sea or By Air
After Service: When you receive the goods, please check the product and its quantity in time, Once
Problems arised , pls contact us and we will help you solve the problem.
1. How about the Delivery time?
We will arrange the delivery within 24 hours after receiving the payment,except for custom products.
2. What kind of payments does you support?
T/T, Western Union, PayPal & Cash are accepted.
3. What's the MOQ?
Generally speaking, the MOQ is 10 gram, but we also can provide you samples for quality inspection.
4. Do you charge for the samples?
According to our company policy, we just charge the samples based on EXW price. And we will return
the samples fee during the next order.
5. Can you packing according to customers' requirements ?
Sure,If you have a request for packing, please tell us,Any good ideas are welcomed.
6. Can you tell me your main customers?
That's our customer's privacy, we should protect their information.
At the same time, please rest assured that your information is also safe here.
We'll offer you the quotation as soon as possible once receive your inquiry, so don't hesitate to contact us.
|How to Proceed Your Orders?|
Please let me know the items you are favorable, quantities, and the destination country.
You confirm all details, and offer us purchasing order.
We send the detail price of our product and offer the suitable shipping method for reference.
You confirm the order and pay money 100% in advance and send us the detailed contacting information,
including contacting person/company, address, mobile number,ZIP code and your special requirements.
Parcel would be arranged within 12 hours upon receipt of your payment .
Photos would be offered to tell apart the products .
Tracking number :
Send by EMS, the tracking number is availabe within 12 hours . The info would be trackable that day or 1
If send by HKEMS or other express,the tracking number would be provided next day. And this does not
mean the info is trackable that day. It would be released on internet 2 or 3 days later . The reason why is
that parcel should be shipped to Hongkong from forwarder then wait for the flight .
You sign for the parcel , deliveried.
We offer after-sales service after you receive parcel.
|Any question, email me, I am sherry.|
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