2mg/Vial Freeze-Dried Polypeptide Powder Follistatin 344 Activin-Binding Protein
|FOB Price:||US $0.5-1 / Vials|
|Min. Order:||10 Vials|
|Min. Order||FOB Price|
|10 Vials||US $0.5-1/ Vials|
|Payment Terms:||T/T, Western Union, Money Gram, Bitcion|
- Model NO.: 99%
- Customized: Customized
- Suitable for: Adult
- Purity: >98%
- Delivery Ways: EMS, Hkems, TNT, DHL, FedEx, UPS etc.
- Other Service: We Confirm 98% Clearance, 100% Resending.
- Price: Negotiable( The Greater The Amount, The Greate)
- Transport Package: as You Requst
- Origin: China
- Powder: Yes
- Certification: ISO 9001, USP, BP, RoHS
- State: Solid
- Delivery Port: Express Courier
- Shipment Time: Within 8 Hours After Confirmation of Your Payment
- MOQ: 10 Vials
- Trademark: ShuCan
- Specification: 98% min
Name: Follistatin 344
Synonyms: FST, FS, Activin-binding protein.
Appearance: Sterile Filtered White Lyophilized (Freeze-Dried)
Purity (by HPLC): 99.00%
Source: Escherichia Coli
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: Lyophilized from a concentrated (1mg / ml) solution containing no additives.
Solubility: It is recommended to reconstitute the lyophilized Follistatin in sterile 18MΩ-cm H2O not less than 100μg / ml, which can then be further diluted to other aqueous solutions.
Stability: Lyophilized Follistatin although stable at room temperature for 3 weeks.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC (b) Analysis by SDS-PAGE..
Storage Conditions: Aviod Shunshine and Keeping Stoppered
Packing: 1mg / vial, 2mg / vial
COA: Follistatin 344
|Appearance||White to off white powder||Consistent|
Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries.
Follistatin is naturally found in the skeletal muscle of almost all mammals with advanced or developed characteristics, such as humans, rodents, and cows. Follistatin is high in the
non-essential amino acid cystine but unlike most proteins discussed in the fitness world, follistatin has carbohydrates attached to it.
Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.
Follistatin (FS) was initially identified as a follicle-stimulating hormone inhibiting substance found in ovarian follicular fluid. FS is a high-affinity activin-binding protein that can act as an activin antagonist. Two alternatively spliced follistatin mRNAs exist, encoding mature FS with 288 amino acid (aa) residues (FS-288) and 315 aa residues (FS-315). Natural FS purified from porcine ovaries is primarily a carboxy-terminal truncated form of FS-315 composed of 300 aa residues.
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).
Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin domains that contain EGFlike and kazallike motifs, and a highly acidic Cterminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids .
Follistatin and Muscle Growth:
Follistatin works by binding to and inhibiting transforming growth factor- (TGF-) peptides such as myostatin which is responsible for regulating and limiting muscle growth. It's also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow.
In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH).  High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function.However, FSH levels that are too low can also negatively impact health and reproductive capabilities.
ACE-031 is intended for research purpose only. ACE-031 should not be used for human consumption, diagnostic, therapeutic procedures, agricultural and veterinary purposes.
ACE-031 is a soluble fusion protein that has been shown to increase muscle mass and strength in research studies. ACE-031 is being studied as a treatment for metabolic diseases, renal neoplasms of childhood, cardiovascular anomalies, age-related muscle loss, and cancer treatment related muscle loss and neuromuscular diseases. ACE-031 is a biologic therapeutic, based on activin receptor type IIB (ActRIIB). The molecule inhibits signaling via the ActRIIB receptor binding and increase muscle mass and strength. ACE-031 is a recombinant fusion protein that is artificially synthesized by fusion of standard antibody and a portion of ActRIIB receptor. The recombinant fusion protein eliminates myostatin and other biomolecules that limit muscle strength or growth.
|State:||Liquid or Powder|
|Appearance:||White Crystalline Powder or Oil|
|Payment:||Western Union, Moneygram, T/T,Bitcion|
|Delivery:||We have stock, so we can delivery quickly at the very day when receive the payment. 100%|
Door to Door
|Shipment:||Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional |
forwarder would be recommanded for you.
|Customs clearance||Don't have to worry about cystoms pass rate,our customs clearance is 100%|
|Product packing||The packing suits you best would be choosen to cross customs safely. Or if you have your |
own ideal way, it could be also take into consideration .
|After-sales service||Warm after-sale service for you 24/7. Any of your question would be solved for the first |
as soon as possible.
|Advantage of Our Company|
1,Professional medical products manufacture for more than 15 years
2,High quality with competitive price
3,Independent Design and Outstanding Sales Team
4,Large Supply Ability
5,Excellent after-sales service
1. Any Inquiries will be replied within 24 hours
2.Hight quality, fashion designs reasonable & competitive price. fast lead time.
3.Payment: You can pay for the order via: T/T, Western Union, MoneyGram
4. After Sale Service:
1).All products will have been strictly Quality Checked in house before packing.
2).All products will be well packed before shipping.
3)Parcel can be sent out in 24 hours after payment. Tracking number available
4)Secure and discreet shipment. Various transportation methods for your choice.
5)Customs pass rate ≥99%
6) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and
we have stock in there for transferring.
we have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air PostYou also can choose
your own shipping forwarder.
Sample Policy:You need pay for sample first if you want to check it and the money will be refunded when
mass order confirmed.
Payment Way: T/T,Western Union, Money Gram
Delivery Date: within 10 working days after deposit paid
Shipping Way: By Sea or By Air
After Service: When you receive the goods, please check the product and its quantity in time, Once
Problems arised , pls contact us and we will help you solve the problem.
1. How about the Delivery time?
We will arrange the delivery within 24 hours after receiving the payment,except for custom products.
2. What kind of payments does you support?
T/T, Western Union, PayPal & Cash are accepted.
3. What's the MOQ?
Generally speaking, the MOQ is 10 gram, but we also can provide you samples for quality inspection.
4. Do you charge for the samples?
According to our company policy, we just charge the samples based on EXW price. And we will return
the samples fee during the next order.
5. Can you packing according to customers' requirements ?
Sure,If you have a request for packing, please tell us,Any good ideas are welcomed.
6. Can you tell me your main customers?
That's our customer's privacy, we should protect their information.
At the same time, please rest assured that your information is also safe here.
We'll offer you the quotation as soon as possible once receive your inquiry, so don't hesitate to contact us.
|How to Proceed Your Orders?|
Please let me know the items you are favorable, quantities, and the destination country.
You confirm all details, and offer us purchasing order.
We send the detail price of our product and offer the suitable shipping method for reference.
You confirm the order and pay money 100% in advance and send us the detailed contacting information,
including contacting person/company, address, mobile number,ZIP code and your special requirements.
Parcel would be arranged within 12 hours upon receipt of your payment .
Photos would be offered to tell apart the products .
Tracking number :
Send by EMS, the tracking number is availabe within 12 hours . The info would be trackable that day or 1
If send by HKEMS or other express,the tracking number would be provided next day. And this does not
mean the info is trackable that day. It would be released on internet 2 or 3 days later . The reason why is
that parcel should be shipped to Hongkong from forwarder then wait for the flight .
You sign for the parcel , deliveried.
We offer after-sales service after you receive parcel.
|Any question, email me, I am sherry.|
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