Gold Member Since 2016
Shanghai Shucan Industrial Co., Ltd.

Vandetanib, 443913-73-3, 4-Quinazolinamine manufacturer / supplier in China, offering Raw Powder Vandetanib 443913-73-3 Oral Inhibitor of Vascular for Anti-Cancer, Steroid Hormones Metandienone Powder Anabolic Steroids Powder CAS 72-63-9, Healthy Muscle Building Steroid Powder Testosterone Enanthate 315-37-7 and so on.

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Supplier Homepage Product Pharmaceutical Raw Materials Raw Powder Vandetanib 443913-73-3 Oral Inhibitor of Vascular for Anti-Cancer

Raw Powder Vandetanib 443913-73-3 Oral Inhibitor of Vascular for Anti-Cancer

FOB Price: US $0.5-1 / Vials
Min. Order: 10 Vials
Min. Order FOB Price
10 Vials US $0.5-1/ Vials
Get Latest Price
Port: Shanghai, China
Production Capacity: 200gram/Month
Payment Terms: T/T, Western Union, Money Gram, Bitcion

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Basic Info
  • Model NO.: 98%
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >98%
  • Delivery Ways: EMS, Hkems, TNT, DHL, FedEx, UPS etc.
  • Other Service: We Confirm 98% Clearance, 100% Resending.
  • Price: Negotiable( The Greater The Amount, The Greate)
  • Transport Package: as You Requst
  • Origin: China
  • Powder: Yes
  • Certification: ISO 9001, USP, BP, RoHS
  • State: Solid
  • Delivery Port: Express Courier
  • Shipment Time: Within 8 Hours After Confirmation of Your Payment
  • MOQ: 10 Vials
  • Trademark: ShuCan
  • Specification: 98% min
Product Description
Vandetanib

1.Basic information:

Product Name:    Vandetanib
Synonyms:    VANDETANIB;4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-;Vandetanib for research;4-(4-Bromo-2-fluoroanilino)-6-methoxy- 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine;Zactima;ZD 6474;7-((4-aminocyclohexyl)methoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
CAS:    443913-73-3
MF:    C22H24BrFN4O2
MW:    475.35    
Product Categories:    Aromatics Compounds;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;ZD6474
Mol File:    443913-73-3.mol

2.Chemical Properties:

Appearance:Yellow Solid
MP    240-2430C
density     1.406
storage temp.     -20?C Freezer

3.Usage And Synthesis

(1).Anticancer drugs

Vandetanib is a kind of small molecule multi-targeted tyrosine kinase inhibitor studied and developed by the British AstraZeneca Company. In April 2011, it was approved the US FDA for entering into market under the trade name Zactima. The drug, as a tablet, can be applied to the treatment of advanced medullary thyroid cancer of adult patients. 
Vandetanib is a multi-targeted tyrosine kinase inhibitor, and belongs to the Anilinoquinazoline compounds, called "second generation Iressa". It not only acts on the tumor cells, EGFR, VEGFR and RET tyrosine kinases, but can also inhibit other kind of tyrosine kinases and serine / threonine kinases. Vandetanib is the first approved drugs approved for treatment of medullary thyroid carcinoma. It is suitable for treating unresectable, locally advanced or metastatic-symptoms or progressive medullary thyroid carcinoma. A randomized, placebo-controlled clinical trial results have showed that vandetanib can significantly delay the progression time of locally advanced or metastatic medullary thyroid cancer. The recommended daily dose is 300 mg (oral), when the patient exhibits tolerance to drugs or being not able to tolerate the toxicity, they should stop treatment immediately. Those most common adverse reactions of this medicine include diarrhea, rash, acne, nausea, hypertension, headache, fatigue, loss of appetite and abdominal pain. The adverse reactions is dose-related; at <300 mg/d, the patient has a well tolerance with the maximum tolerated dose (MTD) being 300mg. There are many kinds disease types contained in the II phase clinical study. The NSCLC clinical trials of vandetanib are currently under way for our country.

(2).Treatment of advanced (non-small cell lung cancer) NSCLC
A study published in the [Journal of Clinical Oncology] have showed that compared with gefitinib which only has inhibitory effect on EGFR, vandetanib can effectively extend the progression-free survival period of the non-small cell lung cancer (NSCLC) patients. 
In this phase II clinical trial conducted by doctors Ronald B. Natale from Los Angeles Cedars-Sinai Cancer Center, clinical study compared the treatment efficacy of vandetanib (300 mg/d) and gefitinib (250mg/d) on 168 cases of NSCLC patients who had been subject to failing first-line or second-line chemotherapy. Compared with gefitinib, vandetanib significantly increased efficiency and prolonged the progression-free survival, period respectively, by 8% and 1%, 11.9 weeks and 8.1 weeks, (P = 0.011). In clinical trials, if there is progression of the disease or if the patient can't tolerate the toxicity, they allowed the patients to change the treatment regimen. Experimental results had shown that using gefitinib for replacing vandetanib in patients gave a disease control rate of 14% while using vandetanib to replace gefitinib gave a disease control rate of 32%. The overall survival period in the case of vandetanib → gefitinib was 6.1 months while it was 7.4 months in the cases of gefitinib → vandetanib.

(3).Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of Vandetanib plus Docetaxel was assessed in patients with previously treated non-small-cell lung cancer (NSCLC).

4.Preparation method    

Use 4-hydroxy-3-methoxy-benzoic acid ethyl ester as a starting material, go through substitution, reduction, nitrification, reduction, cyclization aromatization to give 4-chloro-6-methoxy--7- (N- methyl piperidin-4-ylmethoxy) quinazoline (A), A was then reacted with 4-bromo-2-aniline to obtain the targeted compound vandetanib.


 
Suitable for:Adult
State:Liquid or Powder
Appearance:White Crystalline Powder or Oil
Payment:Western Union, Moneygram, T/T,Bitcion
Delivery:We have stock, so we can delivery quickly at the very day when receive the payment. 100%Door to Door
Polciy:Re-Shipping Policy
Shipment:Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
Price:negotiable
Export Markets:Global
Customs clearanceDon't have to worry about cystoms pass rate,our customs clearance is 100%
Product packingThe packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .
After-sales serviceWarm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.
 +86-17301859715
  
Advantage of Our Company
 
1,Professional medical products manufacture for more than 15 years
2,High quality with competitive price
3,Independent Design and Outstanding Sales Team
4,Large Supply Ability
5,Excellent after-sales service
Our Services
 
1. Any Inquiries will be replied within 24 hours
2.Hight quality, fashion designs reasonable & competitive price. fast lead time.
3.Payment: You can pay for the order via: T/T, Western Union, MoneyGram
4. After Sale Service: 
1).All products will have been strictly Quality Checked in house before packing.
2).All products will be well packed before shipping.
3)Parcel can be sent out in 24 hours after payment. Tracking number available
4)Secure and discreet shipment. Various transportation methods for your choice. 
5)Customs pass rate ≥99%
6) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and 
we have stock in there for transferring.   
5. Shipping
we have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air PostYou also can choose 
your own shipping forwarder.
Buyer Reading
 
Sample Policy:You need pay for sample first if you want to check it and the money will be refunded when 
mass order confirmed.
Payment Way:  T/T,Western Union, Money Gram 
Delivery Date:  within 10 working days after deposit paid 
Shipping Way:  By Sea or By Air 
After Service:  When you receive the goods, please check the product and its quantity in time,  Once  
Problems arised  , pls contact us and we will help you solve the problem.
FAQ
 
1. How about the Delivery time?
We will arrange the delivery within 24 hours after receiving the payment,except for custom products.
2. What kind of payments does you support?
T/T, Western Union, PayPal & Cash are accepted.
3. What's the MOQ?
Generally speaking, the MOQ is 10 gram, but we also can provide you samples for quality inspection.
4. Do you charge for the samples?
According to our company policy, we just charge the samples based on EXW price. And we will return 
the samples fee during the next order.
5. Can you  packing according to customers' requirements  ?
Sure,If you have a request for packing, please tell us,Any good ideas are welcomed.  
6. Can you tell me your main customers?
That's our customer's privacy, we should protect their information.
At the same time, please rest assured that your information is also safe here.
We'll offer you the quotation as soon as possible once receive your inquiry, so don't hesitate to contact us.
 
How to Proceed Your Orders?
 
Step 1
Please let me know the items you are favorable, quantities, and the destination country.
Step 2
You confirm all details, and offer us purchasing order.
Step 3
We send the detail price of our product and offer the suitable shipping method for reference.
Step 4
You confirm the order and pay money 100% in advance and send us the detailed contacting information, 
including contacting person/company, address, mobile number,ZIP code and your special requirements.
Step 5
Parcel would be arranged within 12 hours upon receipt of your payment .
Photos would be offered to tell apart the products .
Tracking number :
Send by EMS, the tracking number is availabe within 12 hours . The info would be trackable that day or 1 
day later.
If send by HKEMS or other express,the tracking number would be provided next day. And this does not 
mean the info is trackable that day. It would be released on internet 2 or 3 days later . The  reason why is 
that  parcel should be shipped to Hongkong from forwarder then wait for the flight .
You sign for the parcel , deliveried.
Step 6
We offer after-sales service after you receive parcel.
Any question, email me, I am sherry.
Tel: +86-17301859715



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250 mg/ml
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400 mg/ml
150 mg/ml
150 mg/ml
100 mg/ml
Methenolone Enanthate 100100mg/ml
 
 
 
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