Cyclosporin a 59865-13-3 Pharmaceuticals in The Prevention of Graft Rejection
|FOB Price:||US $0.5-1 / Vials|
|Min. Order:||10 Vials|
|Min. Order||FOB Price|
|10 Vials||US $0.5-1/ Vials|
|Payment Terms:||T/T, Western Union, Money Gram, Bitcion|
- Model NO.: 98%
- Customized: Customized
- Suitable for: Adult
- Purity: >98%
- Delivery Ways: EMS, Hkems, TNT, DHL, FedEx, UPS etc.
- Other Service: We Confirm 98% Clearance, 100% Resending.
- Price: Negotiable( The Greater The Amount, The Greate)
- Transport Package: as You Requst
- Origin: China
- Powder: Yes
- Certification: ISO 9001, USP, BP, RoHS
- State: Solid
- Delivery Port: Express Courier
- Shipment Time: Within 8 Hours After Confirmation of Your Payment
- MOQ: 10 Vials
- Trademark: ShuCan
- Specification: 98% min
Product Name: Cyclosporin A
Synonyms: ol27-400;s7481f1;sandimmun;sandimmune;ANTIBIOTIC S 7481F1;ANTIBIOTIC S 7481FI;CICLOSPORIN;CICLOSPORIN A
Product Categories: Active Pharmaceutical Ingredients;Organics;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;Protein Phosphatase;Signalling;KAYQUINONE;antibiotic;Anti-cancer&immunity;Inhibitors
Mol File: 59865-13-3.mol
storage temp. 2-8°C
solubility ethanol: 30 mg/mL
color White prismatic needles (from acetone) or white powder.
CAS DataBase Reference 59865-13-3(CAS DataBase Reference)
EPA Substance Registry System Cyclosporin A(59865-13-3)
Hazard Codes T,Xn,F
Risk Statements 45-60-22-40-36-20/21/22-11
Safety Statements 53-45-36/37-24/25-22-26-16
WGK Germany 3
4.Usage And Synthesis:
(1).Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1α, lipopolysaccharides and TNFα.
(2).An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
For prevention of a variety of tissue and organ transplant rejection and treatment of some autoimmune diseases, also used in kidney disease, aplastic anemia, refractory ulcerative colitis. In dermatology, for stubborn and intractable skin diseases, the best effect is severe psoriasis (including vulgaris, pustular, erythrodermic and joint disease); good efficacy on skin disorders including Behcet disease, gangrenous pyoderma, lichen planus, acquired epidermolysis bullosa psychosis; moderate efficacy on disease including alopecia, atopic dermatitis, chronic actinic dermatitis, light class of reticulocyte cell histiocytosis, adult linear IgA bullous dermatitis, pemphigus, bullous pemphigoid (the latter two illness should be in combination with corticosteroids). In addition, Cyclosporine A has effect on systemic lupus erythematosus, dermatomyositis, systemic sclerosis, AIDS, ichthyosis, cutaneous T-cell lymphoma, pityriasis rubra pilaris, generalized missed acrodermatitis, palmoplantar pus blister disease, male pattern baldness, vitiligo, progressive necrotizing xanthogranulomatous, generalized granuloma annulare, lichen myxedema, papular mucin calm disease, hyperthyroidism.
1, In addition to corticosteroids, this product should be avoided in combination with any other immunosuppressive agents.
2, The inactivation of product is mainly in the liver metabolic, any drugs which can affect the liver enzyme activities can affect the metabolism of the product, such as erythromycin, josamycin, ketoconazole, H2 receptor antagonists , calcium antagonists, androgens, oral contraceptives affect activity of cytochrome P-450 liver cell, increase the risk of toxicity of this product.
5, Calcium and increased calcium are disabled when using this product, and cannot be vaccinated.
6, Long-term in combination with glucocorticoid can trigger diabetes, hypertension, ulcer disease and osteoporosis, and can increase the toxicity of this product.
7, Before used Cyclosporin A, other immunosuppressive agents are used, patients have overall decreased immunity and are easy to be infected.
|State:||Liquid or Powder|
|Appearance:||White Crystalline Powder or Oil|
|Payment:||Western Union, Moneygram, T/T,Bitcion|
|Delivery:||We have stock, so we can delivery quickly at the very day when receive the payment. 100%Door to Door|
|Shipment:||Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.|
|Customs clearance||Don't have to worry about cystoms pass rate,our customs clearance is 100%|
|Product packing||The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .|
|After-sales service||Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.|
|Advantage of Our Company|
1,Professional medical products manufacture for more than 15 years
2,High quality with competitive price
3,Independent Design and Outstanding Sales Team
4,Large Supply Ability
5,Excellent after-sales service
1. Any Inquiries will be replied within 24 hours
2.Hight quality, fashion designs reasonable & competitive price. fast lead time.
3.Payment: You can pay for the order via: T/T, Western Union, MoneyGram
4. After Sale Service:
1).All products will have been strictly Quality Checked in house before packing.
2).All products will be well packed before shipping.
3)Parcel can be sent out in 24 hours after payment. Tracking number available
4)Secure and discreet shipment. Various transportation methods for your choice.
5)Customs pass rate ≥99%
6) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and
we have stock in there for transferring.
we have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air PostYou also can choose
your own shipping forwarder.
Sample Policy:You need pay for sample first if you want to check it and the money will be refunded when
mass order confirmed.
Payment Way: T/T,Western Union, Money Gram
Delivery Date: within 10 working days after deposit paid
Shipping Way: By Sea or By Air
After Service: When you receive the goods, please check the product and its quantity in time, Once
Problems arised , pls contact us and we will help you solve the problem.
1. How about the Delivery time?
We will arrange the delivery within 24 hours after receiving the payment,except for custom products.
2. What kind of payments does you support?
T/T, Western Union, PayPal & Cash are accepted.
3. What's the MOQ?
Generally speaking, the MOQ is 10 gram, but we also can provide you samples for quality inspection.
4. Do you charge for the samples?
According to our company policy, we just charge the samples based on EXW price. And we will return
the samples fee during the next order.
5. Can you packing according to customers' requirements ?
Sure,If you have a request for packing, please tell us,Any good ideas are welcomed.
6. Can you tell me your main customers?
That's our customer's privacy, we should protect their information.
At the same time, please rest assured that your information is also safe here.
We'll offer you the quotation as soon as possible once receive your inquiry, so don't hesitate to contact us.
|How to Proceed Your Orders?|
Please let me know the items you are favorable, quantities, and the destination country.
You confirm all details, and offer us purchasing order.
We send the detail price of our product and offer the suitable shipping method for reference.
You confirm the order and pay money 100% in advance and send us the detailed contacting information,
including contacting person/company, address, mobile number,ZIP code and your special requirements.
Parcel would be arranged within 12 hours upon receipt of your payment .
Photos would be offered to tell apart the products .
Tracking number :
Send by EMS, the tracking number is availabe within 12 hours . The info would be trackable that day or 1
If send by HKEMS or other express,the tracking number would be provided next day. And this does not
mean the info is trackable that day. It would be released on internet 2 or 3 days later . The reason why is
that parcel should be shipped to Hongkong from forwarder then wait for the flight .
You sign for the parcel , deliveried.
We offer after-sales service after you receive parcel.
|Any question, email me, I am sherry.|
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